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Brain Perfusion & Parkinson’s: A Vital Connection

Parkinson’s disease (PD) is a progressive neurodegenerative disorder, and understanding brain blood flow is key to improving diagnosis and treatment. Arterial Spin Labeling (ASL) MRI, a non-invasive perfusion imaging technique, provides valuable insights by measuring cerebral blood flow.

Early Detection – Identifies perfusion changes before significant symptoms appear.
Tracking Disease Progression – Monitors blood flow reductions in affected brain regions.
Optimizing Treatment – Helps assess therapy effectiveness and personalize care.
Advancing Research – Aids in drug development and deeper understanding of PD pathology.

ASL MRI is revolutionizing how we detect, monitor, and treat Parkinson’s, paving the way for more precise and effective interventions.

At mediri GmbH, we support you with sophisticated yet easy-to-use ASL image analysis tools, including specialized ASL sequences that can measure exchange time. Our services cover all aspects of ASL imaging.
As a one-stop-shop, we provide comprehensive evaluation services. We specialize in clinical trials that demand precise image data acquisition and quality assurance. Our services include image collection, quality checks, site support, and project management. Perfect for clinical trials requiring longitudinal imaging data or centralized reviews.

On this World Health Day, we emphasize the need for quality healthcare for women before, during, and after pregnancy and childbirth. Women’s health is a cornerstone of thriving families and communities.

At mediri, we take pride in being an employer that champions the health and well-being of our female employees. We are dedicated to creating a supportive workplace that nurtures their health.

Let’s unite in our efforts to ensure every woman receives the care she deserves. Together, we can create a healthier world!

Arterial Spin Labeling (ASL) represents a modern MRI technique for measuring perfusion, which modifies the magnetization of blood water protons to serve as natural tracers.
This method is entirely non-invasive, eliminating the need for ionizing radiation or external contrast agents.
The non-invasive nature of ASL provides numerous benefits for clinical research: it allows for repeated cerebral blood flow (CBF) measurements as often as needed and is suitable for use in vulnerable groups, such as patients with renal failure or pediatric patients.

Why It Matters: ASL offers a safe and effective way to measure cerebral perfusion, making it ideal for various clinical applications.

Have you heard about ASL before? Share your thoughts and experiences with us!

Are you interested in truly non-invasive BBB imaging? We are. That’s why we are investigating in Multi-Echo Arterial Spin Labeling MR imaging techniques (a.k.a. BBB ASL) that enable Tex brain maps.

If you are using ASL sequences for your research you will be familiar with CBF and ATT maps. Our cutting-edge MR sequences together with sophisticated mathematical models go beyond these and produce Tex maps, which show the microvascular exchange dynamics and promise to be an indicator for BBB integrity.

More research in this field is to come and will show how Tex can be used clinically in the future. Be part of this research: Contact us if you want to join us on this exciting journey! 

Not (yet) familiar with the wording? Here you go:

ASL Arterial Spin Labeling is a special MRI technique which uses magnetically labeled blood for perfusion measurements.
BBB Blood Brain Barrier… you have heard of that one.
CBF Cerebral Blood Flow is a measure for brain perfusion.
ATT Arterial Transit Time is the time taken from blood to travel from large arteries in the neck to the cerebral tissue.
Tex exchange Time serves as proxy for BBB permeability to water.

Meet our COO Dr. Julia Müller in Frankfurt to discuss hot topics in Neuroimaging from Perfusion to BBB integrity.
How can we bring perfusion MRI into clinical application? How can we simplify the analysis of Arterial Spin Labeling MR images and provide sophistaced biomarkers for brain perfusion and micro-architecture? I am looking forward to discuss these topics with you at the DGKN e.V. Conference in Frankfurt this week.

Meet our CEO Prof. Dr. Matthias Günther at ISMRM in Pamplona, Spain! 

Join us from 15-17 March 2025 at the ISMRM Workshop on Perfusion MRI and engage with our CEO, Prof. Dr. Matthias Günther. This workshop aims to disseminate cutting-edge research on perfusion MRI and related methods.

Engineers, scientists, and clinicians interested in perfusion MRI techniques and applications, from acquisition to processing strategies, are welcome to join us. Don’t miss this opportunity to connect and learn from the best in the field!

mediri is your dedicated partner for efficient and reliable imaging studies. As your one-stop shop, we provide everything you need – from planning to central read – all under one roof. Benefit from our unique combination of study experience and cutting-edge technological expertise. Our mTRIAL cloud platform enables seamless data exchange, maximum data security in Germany and AI-supported workflows tailored to your study.

At mediri, we are committed to providing exceptional support to our customers and partners. Whether you are seeking expert advice on your imaging study, have questions about medical imaging, or need detailed information about our software solution, mTRIAL, our dedicated team is here to assist you.

We offer:
– Personalized consultations to guide you through your imaging studies
– Expert insights into all aspects of medical imaging
– Comprehensive support for our mTRIAL image data management system

Your success is our top priority, and we are here to ensure you achieve your goals.

…but we also collect other image data and reports from the study sites.

At mediri, we are proud to be at the forefront of medical imaging and clinical imaging trials. Our deep expertise in DICOM (Digital Imaging and Communications in Medicine) and other imaging data formats ensures that we provide comprehensive and seamless support to our study sites.

We are specialized in collecting, managing, and analyzing a wide range of image data and reports from various study sites. This meticulous approach allows us to drive innovation and excellence in medical research, ensuring that our findings are both accurate and impactful.

Our commitment to advancing healthcare through cutting-edge technology and dedicated research is unwavering. By leveraging our extensive knowledge and state-of-the-art tools, we aim to make significant contributions to the medical field.

Since 2004 we have been your trusted service provider for medical image data management in clinical studies. Join us on our journey to transform healthcare and improve patient outcomes.

Exciting times at EUCROF25 Conference!
Our COO, Julia Müller, recently attended the EUCROF Conference in Copenhagen. This fantastic event featured insightful presentations and a wealth of rich topics, particularly on the evolving landscape of Decentralized Clinical Trials (DCTs). It also provided an excellent opportunity to connect with wonderful people.

From discussing the latest trends in clinical research to networking with industry leaders, the conference provided a fantastic platform for knowledge exchange and collaboration. We are excited to bring these new insights back to our team and continue driving innovation in our field.
A big thank you to the organizers and all the participants for making this event a success!
Looking forward to the next one in Amsterdam.

Today we unite for World Cancer Day. This year’s theme, “United by Unique,” underscores the importance of personalized cancer care. Cancer is more than a diagnosis; it’s a personal journey of resilience and hope. Let’s raise awareness, support those battling cancer, and advocate for equitable access to treatments. Together, we can make a difference.

At mediri, we are partners in oncological clinical trials that require meticulous image data acquisition and quality assurance. Our Collect & Hold services offer image collection, quality checks, site support, and project management tailored to early-phase studies. These services are ideal for trials requiring longitudinal imaging data or integrating centralized reviews. We help you achieve the best outcomes for all stakeholders in your study.