Multi-TE ASL in Glioblastoma

How can ASL help visualize tumor aggressiveness in IDH-wildtype glioblastomas?
By quantifying cerebral blood flow (CBF) and permeability (Tex)—non-invasively.
IDH-wildtype glioblastomas (WHO Grade 4) are among the most aggressive brain tumors, characterized by high vascularity and increased blood-brain barrier (BBB) permeability. Arterial Spin Labeling (ASL) MRI could offer a way to visualize these characteristics without the need for contrast agents—potentially benefiting long-term monitoring and patient safety.

We support clinical and oncological research with a comprehensive ASL solution, Our approach includes:
– Scientific consulting for study design and imaging protocols
– Installation of advanced multi-TE ASL sequences
– Quantitative analysis of CBF, ATT, and Tex—a potential marker for BBB integrity
– Secure, pseudonymized data handling via our platform mTRIAL

Why this matters in glioblastoma research?
ASL enables the detection of hyperperfusion in tumor regions—often correlating with tumor grade and aggressiveness. The Tex parameter provides additional insight into BBB disruption, which is typical in high-grade gliomas and may influence drug delivery and treatment response. This makes ASL a powerful tool for non-invasive tumor characterization and therapy monitoring.

Whether you’re conducting a clinical trial or exploring new imaging biomarkers, we are your partner for integrating ASL into neuro-oncological research.
Let’s advance brain tumor imaging—safely, precisely, and without contrast.