Advancements of ASL

30 years after the first successful Arterial Spin Labeling (ASL) MR image acquisition to measure cerebral blood flow in rat brain, the early detection of Alzheimer’s using ASL gains enormous importance with the recent publication of the study results for Lecanemab. Now that there is hope for efficient therapies in dementia diseases, it is a good time to review the steps that have been gone since then. Many initiatives aiming at reliable and comparable quantification of brain perfusion measurements are paving the way for broad usage of ASL in clinical studies focusing on Alzheimer‘s and other dementia diseases.